Anti-Human IL-4 R alpha - 100 µg

CyTOF®, FC, ICC, IHC FFPE, N, WB

IL-4 R alpha

Next Day Ambient

Interleukin 4 receptor (IL-4R) is a type I cytokine receptor that is expressed by lymphocytes and is well known for its role in immunomodulatory signaling and has also been documented on oligodendrocytes, suggesting involvement in glial cell interactions. IL-4R exerts a negative regulatory role on oligodendrocytes that when deleted results in enhanced myelin repair.1 IL-4R in brain tumors may serve as an attractive target for anticancer therapy.2

IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 8-25 µg/ml. The recommended secondary antibody for IHC is PN:M114. For chromogenic detection with high signal and low background use PN:D100 or PN:K107.
Neutralization: This antibody is useful for neutralization of Human IL-4R bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human IL-4R (at 0.2 ng/ml) is 3-6 µg/ml.
Immunocytochemistry: Suitable for use at concentration of 5-15 µg/mL.
CyTOF-ready:Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Mouse Anti-Human Interleukin 4 Receptor (IL-4R) (Clone 25463) recognizes an epitope on Human IL-4R. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody does not cross-react with rhIL-9 R, rmIL-4 R, rhIL-5 Rα, rhIL-5 Rβ, rhIL-13 Rα1 or rhIL-13 Rα2

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Purified Recombinant Human IL-4 R (Accession # P24394)

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