Anti-Human IL-3 Rα (CD123) - 500 µg

CyTOF®, FC, ICC, IHC FFPE, N, WB

IL-3 R alpha

Next Day Ambient

Interleukin 3 receptor alpha (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a type I transmembrane protein that is expressed on the large majority of progenitor cells. IL-3R alpha function can be defined by the activity of its ligand interleukin-3. IL-3 is a multipotent cytokine that promotes the development of hemopoietic progenitors into cells of the erythroid, myeloid and lymphoid lineages.1 CD123 may be a promising strategy for the preferential ablation of acute myelogenous leukemia (AML) cells.2

IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 8 - 25 µg/ml. The recommended secondary antibody for IHC is PN:M114. For chromogenic detection with high signal and low background use PN:D100 or PN:K107.
Neutralization: This antibody is useful for neutralization of Human IL-3 Rα bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human IL-3 Rα (at 0.5 ng/ml) is 0.6 - 1.2 µg/ml.
CyTOF-ready:Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
mmunocytochemistry: Suitable for use at concentration of 8-25 µg/mL.

Mouse Anti-Human Interleukin 3 Soluble Receptor Alpha (IL-3 Rα) (Clone 32703) recognizes an epitope on Human IL-3 Rα. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Purified Recombinant Human IL-3 Rα (Accession # P26951)

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