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Anti-Human IL-13 Rα2 (Clone 83834) - 25 µg

Anti-Human IL-13 Rα2 (Clone 83834) - 25 µg

ArtNr	LEIN-I-688-25ug
Hersteller	Leinco Technologies
Menge	25 ug
Quantity options	100 ug 25 ug 500 ug
Kategorie	Antibodies Western Blot Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB
Clon	83834
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Low, WC. et al. (2003) Neuro Oncol. 5: 179 2. Puri, RK. et al. (2006) Cancer 107: 1407 3. Kitani, A. et al. (2006) Nat Med. 12: 99
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	Quality Tested by Leinco Western Blotting: To detect Human IL-13 Rα2 this monoclonal antibody can be used at a concentration of 5 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:M114 and a chromogenic substrate such as PN:T343. The detection limit for rhIL-13 Rα2 is approximately 25 ng/lane and 5 ng/lane under non-reducing and reducing conditions, respectively. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used.
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	IL-13 R alpha 2
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	Interleukin 13 receptor alpha 2, also known as IL13RA2 and CD213A2, binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. IL13RA2 serves as a dominant negative inhibitor or a decoy receptor for IL-13.1 IL-13Ralpha2 is a promising target for ovarian cancer therapy, and the soluble form of IL-13R may be a possible surrogate marker for disease monitoring.2 IL13RA2 signaling during prolonged inflammation is also an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis.3
Background	Interleukin 13 receptor alpha 2, also known as IL13RA2 and CD213A2, binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. IL13RA2 serves as a dominant negative inhibitor or a decoy receptor for IL-13.¹ IL-13Ralpha2 is a promising target for ovarian cancer therapy, and the soluble form of IL-13R may be a possible surrogate marker for disease monitoring.² IL13RA2 signaling during prolonged inflammation is also an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis.³
PubMed	IL-13 R alpha 2
Manufacturer - Specificity	Mouse Anti-Human Interleukin-13 Receptor Alpha 2 (IL-13 Rα2) (Clone 83834) recognizes an epitope on Human IL-13 Rα2. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody shows no cross-reactivity with rhIL-5 Rα, rhIL-5 Rβ, rhIL-13 Rα1 and rmIL-13 Rα2 and approximately 5% cross-reactivity with rhIL-4 R and rhIL-9 R.
RRID	AB_2830809
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Immunogen	NS0-Derived Recombinant Human Interleukin-13 Receptor α2 Extracellular Domain (Accession # Q14627)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Interleukin-13 Receptor Alpha 2, IL13RA2, CD213A2, IL-13R, IL13BP, 83834, IL-13 Rα2, Human, Anti-Human IL-13 Rα2, cancer/testis antigen 19, CD213a2 antigen, CD213a2, CT19, IL-13 R alpha 2, IL-13 receptor subunit alpha-2, IL13BP, IL13R alpha 2, IL-13R subunit alpha-2, IL13R, IL-13R, IL13RA2, IL-13Ra2, IL-13R-alpha-2, interleukin 13 binding protein, interleukin 13 receptor alpha 2 chain, interleukin 13 receptor, alpha 2, interleukin-13 receptor subunit alpha-2, Interleukin-13-binding protein

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LEIN-I-688-25ug-safety-datasheet.pdf