Anti-Human IGFBP-1 (Clone 33627) - 100 µg

ELISA Cap, N, WB

IGFBP-1

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Insulin-like growth factor binding protein 1, also known as IGFBP1, is a member of the insulin-like growth factor binding protein (IGFBP) family that are cysteine-rich proteins that act as a carrier protein. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-1 is particularly important in female reproductive physiology, where it is involved with other factors in a complex system which regulates menstrual cycles, puberty, ovulation, decidualization, implantation and fetal growth. There is evidence for a pathophysiological role for IGFBP-1 in pre-eclampsia, intrauterine growth restriction, polycystic ovarian syndrome and trophoblast and endometrial neoplasms.1

Neutralization: This antibody is useful for neutralization of Human IGFBP-1 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human IGFBP-1 (at 5.0 ng/ml) is 10 - 40 µg/ml.

Mouse Anti-Human Insulin-Like Growth Factor Binding Protein 1 (IGFBP-1) (Clone 33627) recognizes an epitope on Human IGFBP-1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Purified Recombinant Human IGFBP-1 (> 98%)

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