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Anti-Human IFN-γ R1 - 25 µg

ArtNr LEIN-I-730-25ug
Hersteller Leinco Technologies
Menge 25 ug
Quantity options 100 ug 25 ug
Kategorie
Typ Antibody Primary
Applikationen WB, ICC
Specific against Human (Homo sapiens)
Host Caprine
Citations 1. Calderon, J. et al. (1988) PNAS 85: 4837
2. Garcia-Sastre, A. et al. (2002) Int. Rev. Immunol. 21: 305
3. Fish, E. et al. (2002) J. Interferon Cytokine Res. 22: 835
NCBI 3459
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Applications
ICC, N, WB
Manufacturer - Category
Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets
IFN-gamma R1
Country of Origin
USA
Shipping Temperature
Next Day Ambient
Storage Conditions
The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description
IFN-γ receptor ligand-binding chain (IFNγR1) or IFN-γ R α chain, also known CDw119, is member of the class II cytokine receptor family. The IFN-γ receptor is a complex of a high affinity IFN-γ-binding chain (aka, IFN-γ R α chain) and a second accessory protein required for signal transduction known as IFN-γ R β chain. Binding of IFN-γ induces receptor dimerization and internalization. Signal transduction involves Jak1 and Jak2 protein kinases and involves STAT1 activation. The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.1, 2, 3
Background
IFN-γ receptor ligand-binding chain (IFNγR1) or IFN-γ R α chain, also known CDw119, is member of the class II cytokine receptor family. The IFN-γ receptor is a complex of a high affinity IFN-γ-binding chain (aka, IFN-γ R α chain) and a second accessory protein required for signal transduction known as IFN-γ R β chain. Binding of IFN-γ induces receptor dimerization and internalization. Signal transduction involves Jak1 and Jak2 protein kinases and involves STAT1 activation. The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.1, 2, 3
Other Applications Reported In Literature
Neutralization: This antibody is useful for neutralization of Human IFN-γ R1 bioactivity. The antibody dose required to neutralize 50% (ND50) of the biological activity of Human IFN-γ R1 (at 2 ng/ml) is 0.5 - 2.0 µg/ml.
Immunocytochemistry: Suitable for use at concentration of5-15 µg/mL.
PubMed
IFN-gamma R1
Manufacturer - Specificity
Goat Anti-Human Interferon Gamma Receptor 1 (IFN-γ R1) recognizes Human IFN-γ R1. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID
AB_2830851
Formulation
This antigen affinity purified polyclonal antibody has been 0.2 µm filtered in modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 with concentration 1.648 and no calcium, magnesium, or preservatives present.
Endotoxin Level
< 0.1 EU/µg as determined by the LAL method
Immunogen
NS0-Derived Recombinant Human Interferon-γ Receptor 1 Extracellular Domain
Additional Information
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords
Polyclonal Antibody, Interferon Gamma Receptor 1, CD119, IFN-γR, IFN-γRα, IFN-α R1, CDw119, IFN-γ R1, Human IFN-γ R1, Anti-Human IFN-γ R1, AVP, type 2; CD119 antigen, CD119, FLJ45734, IFN-gamma R1, IFN-gamma receptor 1, IFNgammaR1, IFN-gamma-R1, IFNGR, IFNGR1, IFN-gR1, immune interferon receptor 1, interferon gamma receptor 1, interferon-gamma receptor alpha chain, type 2

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 25 ug
Lieferbar: In stock
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