Anti-Mouse ICAM-2 - 100 µg

B, IHC FFPE, WB

ICAM-2

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Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins that bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 2 - 15 µg/ml. The recommended secondary antibody for IHC is PN:G505. For chromogenic detection with high signal and low background use PN:D100 or PN:K107.
Blocking: This antibody shows inhibition in the HSB2 adhesionassay. The adhesion of PMA treated human HSB2 cells (5 x 104 cells/well) to12.5 μg/mL immobilized rmICAM-2/Fc (100 μL/well) was maximally inhibited(80 - 100%) following pre-treatment with antibody for 1 hour using 100 μL of a25 μg/mL antibody solution per well.

Goat Anti-Mouse Intercellular Adhesion Molecule-2 (ICAM-2) recognizes Mouse ICAM-2. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

NS0-Derived Recombinant Mouse ICAM-2 Extracellular Domain

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