Anti-Human IGFBP-4 - 100 µg

IHC FFPE, N, WB

IGFBP-4

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Insulin-like growth factor binding protein 4, also known as IGFBP4, is a member of the insulin-like growth factor binding protein (IGFBP) family that are cysteine-rich proteins that act as a carrier protein. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. The protein itself does not prevent the formation of cancer.1 However it may reduce the growth of cancer and act as an apoptotic factor.

IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 5-15 µg/mL. The recommended secondary antibody for IHC is PN:G505. For chromogenic detection with high signal and low background use PN:D100 or PN:K107.
Neutralization: This antibody is useful for neutralization of Human IGFBP-4 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human IGFBP-4 (at 0.3 ng/ml) is 12 - 60 µg/ml.

Goat Anti-Human Insulin-Like Growth Factor Binding Protein 4 (IGFBP-4) recognizes Human IGFBP-4. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

NS0-Derived Recombinant Human IGFBP-4

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