Anti-Human CD119 (IFN-gamma Ralpha Chain) - DyLight 755

Antibody Details

Product Details

Reactivity Species

Human

Host Species

Mouse

Immunogen

Purified Recombinant Human IFNGR1 (> 98%)

Product Concentration

0.1 mg/ml

Formulation

This DyLight^® 755 conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.

Storage and Handling

This DyLight^® 755 conjugate is stable when stored at 2-8°C. Do not freeze.

Country of Origin

USA

Shipping

Next Day 2-8°C

RRID

AB_2831051

Applications and Recommended Usage?
Quality Tested by Leinco

FC The suggested concentration for clone GIR-208 conjugated antibody for staining cells in flow cytometry is ≤ .25 μg per 10⁶ cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Clone GIR-208 recognizes an epitope on human IFNγ Rα.

Antigen Distribution

The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.

Background

IFNγ Rα, or IFNγ R1, is a 90-100 kD type I transmembrane protein that is structurally related to IL-10 receptor. IFNγ Receptor consists of α and ß chains and requires association of JAK1, JAK2 and Stat1 for IFN-γ signal transduction which induces tyrosine phosphorylation of IFN-γ Rα leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-γ induced gene transcription.

Antigen Details

Protein

IFNγ Rα

PubMed

IFNγ Rα

NCBI Gene Bank ID

3459

UniProt.org

Information on Uniprot.org

Research Area

Immunology

Technical Protocols