Anti-Human Leptin (Clone 44802) - 25 µg

ELISA Cap, N

Leptin

Next Day Ambient

Leptin is a neuroendocrine hormone secreted from adipose tissue that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin is one of the most important adipose derived hormones.1 It interacts with six types of receptors and once it binds to OB-Receptor it activates the stat3, which is phosphorylated and travels to the nucleus to effect changes in gene expression. One of the main effects on gene expression is the down-regulation of the expression of endocannabinoids.2 High leptin levels are associated with psoriasis.3

Neutralization: This antibody is useful for neutralization of Human OB bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human OB (at 7.5 ng/ml) is 0.4 - 1.6 µg/ml.

Mouse Anti-Human Leptin (Clone 44802) recognizes an epitope on Human Leptin. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

E. coli-Derived Recombinant Human Leptin (Accession # P41159)

Monoclonal Antibody, Leptin, Obesity Protein (OB), B219, LEP, OBS, 44802, Human, Anti-Human Leptin, FLJ94114, LEP, leptin (murine obesity homolog), leptin (obesity homolog, mouse), Leptin, OB, Obese protein, obese, mouse, homolog of, Obesity factor, OBOBS