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Anti-Human TGF-β1 (Clone 27235) - 500 µg

Anti-Human TGF-β1 (Clone 27235) - 500 µg

ArtNr	LEIN-L208-500ug
Hersteller	Leinco Technologies
Menge	500 ug
Quantity options	100 ug 25 ug 500 ug
Kategorie	Antibodies Immunocytochemistry Primary Antibodies Immunochemistry
Typ	Antibody Monoclonal
Applikationen	ICC
Clon	27235
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Guven, M. et al. (2007) Growth Factors 25: 101 2. Schneider, J. et al. (2009) J Investing Med. 57(5):655-61 3. Yu, C. et al. (2009) Biochem Biophys Res Commun. 406(2):204-210
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	ICC, N
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	TGF-beta 1
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	Transforming growth factor beta 1 or TGF-β1 is a multifunctional cytokine that regulates the proliferation and differentiation of cells specific to bone like chondrocytes, osteoblasts, osteoclasts including mesenchymal precursor cells.1 It is known to promote the pathogenesis of lung fibrosis and acts as a tumor suppressor in normal cells.2 TGF-beta1 can promote mechanical strength in healing Achilles tendons by regulating collagen synthesis, cross-link formation, and matrix remodeling.3
Background	Transforming growth factor beta 1 or TGF-β1 is a multifunctional cytokine that regulates the proliferation and differentiation of cells specific to bone like chondrocytes, osteoblasts, osteoclasts including mesenchymal precursor cells.¹ It is known to promote the pathogenesis of lung fibrosis and acts as a tumor suppressor in normal cells.² TGF-beta1 can promote mechanical strength in healing Achilles tendons by regulating collagen synthesis, cross-link formation, and matrix remodeling.³
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Human LAP (TGF-β1) bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human LAP (TGF-β1) (at 125 ng/ml) is 0.5-1.0 µg/ml. Immunocytochemistry: Suitable for use at concentration of 3-25 µg/mL.
PubMed	TGF-beta 1
Manufacturer - Specificity	Mouse Anti-Human Latency Associated Peptide (LAP) (Clone 27235) recognizes an epitope on Human LAP. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2831140
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human TGF-β1 (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Transforming Growth Factor-Beta 1, TGFB , TGFB1, Differentiation Inhibiting Factor, Cartilage-Inducing Factor, Latency Associated Peptide (LAP), CED, 27235, TGF-β1, Human, Anti-Human TGF-β1, CED, DPD1, LAP (TGFbeta 1), LAP (TGF-beta 1), LAP, TGFB, TGFB1, TGFbeta, transforming growth factor beta 1

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LEIN-L208-500ug-safety-datasheet.pdf