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Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP1-E2) - Purified No Carrier Protein - 500 µg

Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP1-E2) - Purified No Carrier Protein - 500 µg

ArtNr	LEIN-LT7040-500ug
Hersteller	Leinco Technologies
Menge	500 ug
Quantity options	100 ug 500 ug
Kategorie	Antibodies ELISA Primary Antibodies Immunostaining
Typ	Antibody Monoclonal
Applikationen	ELISA
Clon	NP1-E2
Specific against	Virus, SARS-CoV-2
Host	Mouse
Purity	≥95% monomer by analytical SEC
NCBI	43740575
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Applications	Quality Tested by Leinco ELISA
Manufacturer - Category	Primary Monoclonal Antibodies>Infectious Diseases\|Monoclonal Antibodies\|Recombinant Antibodies\|SARS-CoV-2
Manufacturer - Targets	SARS-CoV-2 Nucleocapsid (N)
Country of Origin	USA
Shipping Temperature	Ships Overnight on Blue Ice
Storage Conditions	This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.
Product Description	Coronavirus disease 2019 (COVID-19) is caused by the Coronaviridae family virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1. SARS-CoV-2 has four structural proteins encoded by its single-stranded, positive-sense RNA genome: the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins2. The N protein is a highly conserved 46 kDa protein that shares 90% homology with SARS-CoV3. The N protein has an N-terminal (NTD) and C-terminal domain (CTD), which bind to RNA and self-oligomerize, respectively4, 5, forming a helical nucleocapsid structure within the viral envelope6. Other functions of the N protein included viral transcription, replication, and modulating cell signaling pathways7, 8. The N protein is abundantly expressed during infection, and antibodies3, 9 and memory T cells10, 11 targeting the N protein have been identified in convalescent sera. Therefore, the N protein is a target in some vaccines and diagnostic assays12. The N protein also has therapeutic potential, as it evades RNAi-mediated antiviral responses13.
Background	Coronavirus disease 2019 (COVID-19) is caused by the Coronaviridae family virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)¹. SARS-CoV-2 has four structural proteins encoded by its single-stranded, positive-sense RNA genome: the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins². The N protein is a highly conserved 46 kDa protein that shares 90% homology with SARS-CoV³. The N protein has an N-terminal (NTD) and C-terminal domain (CTD), which bind to RNA and self-oligomerize, respectively^{4, 5}, forming a helical nucleocapsid structure within the viral envelope⁶. Other functions of the N protein included viral transcription, replication, and modulating cell signaling pathways^{7, 8}. The N protein is abundantly expressed during infection, and antibodies^{3, 9} and memory T cells^{10, 11} targeting the N protein have been identified in convalescent sera. Therefore, the N protein is a target in some vaccines and diagnostic assays¹². The N protein also has therapeutic potential, as it evades RNAi-mediated antiviral responses¹³.
PubMed	SARS-CoV-2 Nucleocapsid (N)
Manufacturer - Research Area	COVID-19, Infectious Disease, Seasonal and Respiratory Infections, Viral, IVD Raw Material
Manufacturer - Expression host	HEK-293
Manufacturer - Specificity	Anti-SARS-CoV-2 Nucleocapsid, clone NP1-E2, specifically targets an epitope on the SARS-CoV-2 nucleocapsid protein. Furthermore, it is reported to bind to the RNA binding domain of the N protein.
RRID	AB_2893995
Concentration	≥1.0 mg/ml
Formulation	This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Antigen Distribution	The nucleocapsid protein is expressed in the internal nucleocapsid of SARS-CoV-2.
Immunogen	SARS-CoV-2 Nucleocapsid (N) Protein
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	SARS-CoV-2 Nucleocapsid, SARS-CoV-2 Nucleoprotein, Protein N, SARS-CoV N Protein, Monoclonal Antibody, COVID-19

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LEIN-LT7040-500ug-safety-datasheet.pdf