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Anti-Human MMP-1 - 25 µg

ArtNr LEIN-M1299-25ug
Hersteller Leinco Technologies
Menge 25 ug
Quantity options 100 ug 25 ug
Kategorie
Typ Antibody Primary
Applikationen WB, ICC, ELISA
Specific against Human (Homo sapiens)
Host Caprine
Citations 1. Brinckerhoff, CE. et al. (1987) Oncology 64: 337
2. Saffarian, S. et al. (2004) Science 306: 108
3. Sunami, E. et al. (1987) Oncologist 5: 108
NCBI 4312
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Applications
ELISA Cap, ICC, WB
Manufacturer - Category
Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets
MMP-1
Country of Origin
USA
Shipping Temperature
Next Day Ambient
Storage Conditions
The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description
Matrix metallopeptidase 1 (interstitial collagenase), also known as MMP1 is an enzyme involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP-1 is the only enzyme able to initiate breakdown of the interstitial collagens, collagen type 1, collagen type 2, and collagen type 3.1, 2 MMP-1 plays an important role in diverse physiologic processes such as development, tissue morphogenesis, and wound repair. Expression of MMP-1 is a prognostic marker for hematogenous metastasis of colorectal cancer.3
Background
Matrix metallopeptidase 1 (interstitial collagenase), also known as MMP1 is an enzyme involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP-1 is the only enzyme able to initiate breakdown of the interstitial collagens, collagen type 1, collagen type 2, and collagen type 3.1, 2 MMP-1 plays an important role in diverse physiologic processes such as development, tissue morphogenesis, and wound repair. Expression of MMP-1 is a prognostic marker for hematogenous metastasis of colorectal cancer.3
Other Applications Reported In Literature
Immunocytochemistry: This antibody can be used at 2 - 15 μg/mL to detect human MMP-1 in 10 - 15 μm thick paraffin-embedded tissue sections.
PubMed
MMP-1
Manufacturer - Specificity
Goat Anti-Human Matrix Metalloproteinase 1 (MMP-1) recognizes Human MMP-1. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID
AB_2831294
Formulation
This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Immunogen
CHO Cell-Derived Recombinant Human MMP-1
Additional Information
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords
Polyclonal Antibody, MMP-1, Collagenase (CLGN), CLG, Collagenase-1 (CLG1), Fibroblast Collagenase, Fibroblast-Type Collagenase, Interstitial Collagenase, Tissue Collagenase, MMP-1, Human MMP-1, Anti-Human MMP-1, CLGmatrix metalloprotease 1, CLGN, EC 3.4.24; EC 3.4.24.7, Fibroblast collagenase, interstitial collagenase, matrix metallopeptidase 1 interstitial collagenase, matrix metalloproteinase 1 interstitial collagenase, Matrix metalloproteinase-1, MMP1, MMP-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 25 ug
Lieferbar: In stock
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