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Anti-Human MIP-3α - 100 µg

ArtNr LEIN-M182-100ug
Hersteller Leinco Technologies
Menge 100 ug
Quantity options 100 ug 25 ug
Kategorie
Typ Antibody Primary
Applikationen IHC, ICC
Specific against Human (Homo sapiens)
Host Caprine
Citations 1. Nomiyama, H. et al. (1997) J. Biol. Chem. 272: 5846
2. Kucharzik, T. et al. (2005) J. Pathol. 166: 1647
3. Cook, DN. et al. (2000) Immunity 12: 495
4. Farber, JM. et al. (2002) J. Immunol. 168: 4871
NCBI 6364
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Applications
ICC, IHC FFPE, N
Manufacturer - Category
Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets
MIP-3 alpha
Country of Origin
USA
Shipping Temperature
Next Day Ambient
Storage Conditions
The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description
Macrophage Inflammatory Protein-3 Alpha (MIP3A) also known as CCL20 or liver activation regulated chemokine (LARC) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.1 MIP3A is specifically expressed by the follicle-associated epithelia (FAE) covering intestinal Peyer's patches (PPs) and is the only known chemokine ligand for the chemokine receptor CCR6.2 MIP3-alpha is produced by intestinal epithelial cells (including cells associated with mucosal lymphoid tissues), by keratinocytes in inflamed skin, and by cells in liver and lung.3, 4 It plays an important role in the inflammatory response of blood monocytes and tissue macrophages.
Background
Macrophage Inflammatory Protein-3 Alpha (MIP3A) also known as CCL20 or liver activation regulated chemokine (LARC) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.1 MIP3A is specifically expressed by the follicle-associated epithelia (FAE) covering intestinal Peyer's patches (PPs) and is the only known chemokine ligand for the chemokine receptor CCR6.2 MIP3-alpha is produced by intestinal epithelial cells (including cells associated with mucosal lymphoid tissues), by keratinocytes in inflamed skin, and by cells in liver and lung.3, 4 It plays an important role in the inflammatory response of blood monocytes and tissue macrophages.
Other Applications Reported In Literature
IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 5 - 15 µg/ml. The recommended secondary antibody for IHC is PN:G505. For chromogenic detection with high signal and low background use PN:D100 or PN:K107.
Immunocytochemistry: Suitable for use at concentration of5-15 µg/mL.
Neutralization: This antibody is useful for neutralization of Human MIP-3α bioactivity. The antibody dose required to neutralize 50% (ND50) of the biological activity of Human MIP-3α (at 10 ng/ml) is 0.2 - 1 µg/ml.
PubMed
MIP-3 alpha
Manufacturer - Specificity
Rabbit Anti-Human Macrophage Inflammatory Protein-3 Alpha (MIP-3α) recognizes Human MIP-3α. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID
AB_2831366
Formulation
This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level
< 0.1 EU/µg as determined by the LAL method
Immunogen
Purified Recombinant Human MIP-3α (> 98%)
Additional Information
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords
Polyclonal Antibody, MIP-3α, CKb4, Liver Activation Regulated Chemokine (LARC), MIP3A, SCYA20, ST38, Exodus-1, MIP-3α, Human MIP-3α, Anti-Human MIP-3α, beta chemokine exodus-1, Beta-chemokine exodus-1, CC chemokine LARC, C-C motif chemokine 20, CCL20, chemokine C-C motif ligand 20, CKb4, exodus-1, LARC, LARCLiver and activation-regulated chemokine, MIP3 alpha, MIP-3 alpha, MIP-3a, MIP-3-alpha, MIP3AMacrophage inflammatory protein 3 alpha, SCYA20Small-inducible cytokine A20, small inducible cytokine subfamily A Cys-Cys, member 20, ST38

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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