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Anti-Human NT-3 (Clone41512) - 25 µg

Anti-Human NT-3 (Clone41512) - 25 µg

ArtNr	LEIN-N200-25ug
Hersteller	Leinco Technologies
Menge	25 ug
Quantity options	100 ug 25 ug 500 ug
Kategorie	Antibodies ELISA Primary Antibodies Immunostaining
Typ	Antibody Monoclonal
Applikationen	ELISA
Clon	41512
Specific against	Human (Homo sapiens)
Host	Mouse
Citations	1. Barde, YA. et al. (1990) Progress in Growth Factor Res. 2: 237 2. Thoenen, H. et al. (1991) Trends in Neurological Scienc. 14: 165 3. Vantini, G. et al. (1992) Psychoneuroendocrinology 17: 401 4. Verge, VM. et al. (2005) J Neurosci. 25(3):758-67
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	ELISA Cap, N
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	NT-3
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	Neurotrophin 3 (NT-3), also known as NTF3 is a basic protein found in neurons of the central nervous system. NT-3 selectively supports the survival of neuronal cell populations. It rapidly potentiate the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture and thus appears to be involved in the regulation of functions of developing synapses.1, 2, 3 NT-3 negatively modulates nerve growth factor (NGF) receptor expression and associated nociceptive phenotype in intact neurons, suggesting a beneficial role in treating aspects of neuropathic pain mediated by NGF. NT-3 is effective at suppressing thermal hyperalgesia associated with chronic constriction injury (CCI).4
Background	Neurotrophin 3 (NT-3), also known as NTF3 is a basic protein found in neurons of the central nervous system. NT-3 selectively supports the survival of neuronal cell populations. It rapidly potentiate the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture and thus appears to be involved in the regulation of functions of developing synapses.^{1, 2, 3} NT-3 negatively modulates nerve growth factor (NGF) receptor expression and associated nociceptive phenotype in intact neurons, suggesting a beneficial role in treating aspects of neuropathic pain mediated by NGF. NT-3 is effective at suppressing thermal hyperalgesia associated with chronic constriction injury (CCI).⁴
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Human NT-3 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human NT-3 (at 100 ng/ml) is 0.1 - 0.5 µg/ml.
PubMed	NT-3
Manufacturer - Specificity	Mouse Anti-Human Neurotrophin 3 (NT-3) (Clone 41512) recognizes an epitope on Human NT-3. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2831433
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human NT-3 (Accession # P20783)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Neurotrophin-3, Nerve Growth Factor-2 (NGF-2), HGN NTF3, HDNF, MGC129711, 41512, NT-3, Human, Anti-Human NT-3, 3-nucleotidase, HDNF, MGC129711, Nerve growth factor 2, Neurotrophic factor, neurotrophin 3, neurotrophin-3, NGF2, NGF-2, NT3, NT-3, NTF3

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LEIN-N200-25ug-safety-datasheet.pdf