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Anti-Human Tyrosine Kinase Substrate p62dok (CT)

Anti-Human Tyrosine Kinase Substrate p62dok (CT)

ArtNr	LEIN-P161-1mg
Hersteller	Leinco Technologies
Menge	1 mg
Quantity options	0.1 mg 0.5 mg 1 mg 20 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Carpino, N. et al. (1997) Cell 88:197 2. Yamanashi, Y. et al. (1997) Cell 88:205 3. Holland, SJ. et al. (1997) EMBO J. 16:3877 4. Di Cristofano, A. et al. (1998) J. Biol. Chem. 273:4827
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	Tyrosine Kinase Substrate p62dok
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF and insulin receptors was identified recently from human and mouse by several laboratories. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP). p62dok represents a new family with very recently identified p56dok.
Background	Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF and insulin receptors was identified recently from human and mouse by several laboratories. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP). p62dok represents a new family with very recently identified p56dok.
PubMed	Tyrosine Kinase Substrate p62dok
Manufacturer - Specificity	Rabbit Anti-Human Tyrosine Kinase Substrate p62^dok (p62 DOK) recognizes an epitope near the C-terminus of Human p62 DOK. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2831532
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:P188
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

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LEIN-P161-1mg-safety-datasheet.pdf