Anti-Human RP105 (NT) - 0.1 mg

IHC FFPE, WB

RP105

Next Day Ambient

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products duringinfection and serve as an important link between the innate and adaptive immune responses (1, 2). The signaling of these TLRs is kept under tight control by theexpression of endogenous inhibiting proteins. One such protein is RP105, a recently identified homolog to TLR4 that, with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway (3). It has also been suggested that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes (4). Despite its predicted molecular weight, RP105 often migrates at 95 – 105 kDa.

RP105

AB_2831690

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.