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Anti-Human TACE (CT) - 0.1 mg

Anti-Human TACE (CT) - 0.1 mg

ArtNr	LEIN-T203-0.1mg
Hersteller	Leinco Technologies
Menge	0.1 mg
Quantity options	0.1 mg 20 ug
Kategorie	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Masson, D. et al. (2009) Int J Mol Med. 23: 41 2. Chodynicka, B. et al. (2008) J European Acad Dermatol & Venereol. 22: 712 3. Coffey, RJ. et al. (2008) Clin Cancer Res. 14: 1182 4. Blobel, CP. et al. (2007) J Immunol. 179: 2689
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	TACE
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	TACE (tumor necrosis factor-α-converting enzyme) is a pleiotropic metalloprotease also known as ADAM17 that is found to be constitutively expressed by intestinal epithelial cells.1 TACE is a major sheddase of TNF-α and its receptors, essential for the generation of soluble, mature molecules.2 TACE as a promising target of epidermal growth factor receptor (EGFR) axis inhibition in colorectal cancer (CRC)3 and a principal target for the treatment of TNF-dependent pathologies.4
Background	TACE (tumor necrosis factor-α-converting enzyme) is a pleiotropic metalloprotease also known as ADAM17 that is found to be constitutively expressed by intestinal epithelial cells.¹ TACE is a major sheddase of TNF-α and its receptors, essential for the generation of soluble, mature molecules.² TACE as a promising target of epidermal growth factor receptor (EGFR) axis inhibition in colorectal cancer (CRC)³ and a principal target for the treatment of TNF-dependent pathologies.⁴
PubMed	TACE
Manufacturer - Specificity	Rabbit Anti-Human TNF-α Converting Enzyme (TACE) recognizes an epitope near the C-terminus of Human, Mouse and Rat TACE. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2831851
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:T204
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Tumor Necrosis Factor-α Converting Enzyme, ADAM17, CD156b, MGC71942, cSVP, TACE, Human, Anti-Human TACE (CT), TACE Antibody, CSVP, TACE, NISBD, ADAM18, CD156B, CSVP, Disintegrin and metalloproteinase domain-containing protein 17, Snake venom-like protease, ADAM 17

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LEIN-T203-0.1mg-safety-datasheet.pdf