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Anti-Human TNF Receptor-Associated Factor 3 (CT-2) (TRAF3) - 0.1 mg

Anti-Human TNF Receptor-Associated Factor 3 (CT-2) (TRAF3) - 0.1 mg

ArtNr	LEIN-T285-0.1mg
Hersteller	Leinco Technologies
Menge	0.1 mg
Quantity options	0.1 mg 20 ug
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Antibodies By Cell Type Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Arch, RH. et al. (1998) Genes Dev. 12:2821 2. Cheng, G. et al. (1995) Science 267:1494 3. Mosialos, G. et al. (1995) Cell 80:389 4. van Eyndhoven, WG. et al. (1999) Mol. Immunol. 36:647
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	TNF Receptor-Associated Factor 3
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily.1 TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1.2, 3 Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-κB.4 Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-β receptor (LTβR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTβR.
Background	Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily.¹ TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1.^{2, 3} Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-κB.⁴ Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-β receptor (LTβR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTβR.
PubMed	TNF Receptor-Associated Factor 3
Manufacturer - Specificity	Rabbit Anti-Human TNF Receptor-Associated Factor 3 (TRAF3) recognizes an epitope near the C-terminus of Human, Mouse and Rat TRAF3. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2831882
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

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LEIN-T285-0.1mg-safety-datasheet.pdf