Anti-Human Tetratricopeptide Repeat Protein 5 (TTC5)

Tetratricopeptide Repeat Protein 5

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Tetratricopeptide repeat protein 5 (TTC5) is a member of a diverse group of functionally distinct proteins that are characterized by containing one or more tetratricopeptide repeats.1 Each motif consists of two anti-parallel a-helices such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that may serve to accommodate the complementary region of a target protein. While the exact function of TTC5 remains unclear, it is thought that the TPR motifs serve to mediate protein-protein interactions such as those seen with protein chaperones HSP70 and HSP90, 2 and some proteins involved in cell stress response signaling pathways such as protein phosphatase 5, 3 suggesting that TTC5 may also function via protein-protein interactions mediated by its TPR motifs.

Tetratricopeptide Repeat Protein 5

AB_2831892

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.