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Anti-Human TRIM5delta

Anti-Human TRIM5delta

ArtNr	LEIN-T335-0.5mg
Hersteller	Leinco Technologies
Menge	0.5 mg
Quantity options	0.1 mg 0.5 mg 1 mg 20 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Reymond, A. et al. (2001) EMBO J. 20:2140 2. Stremlau, M. et al. (2004) Nature 427:848 3. Hatziioannou, T. et al. (2004) Proc. Nat’l. Acad. Sci. USA 101:10774 4. Xu, L. et al. (2003) Exp. Cell Res. 288:84
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Primary Monoclonal Antibodies>Infectious Diseases
Manufacturer - Targets	TRIM5δ
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region.1 TRIM5 has five alternately spliced isoforms, the longest of which is the variant which also contains a carboxy-terminal B30.2 (SPRY) domain.1 Expression of TRIM5α variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, 2, 3 albeit at differing efficiencies. The TRIM5δ isoform has been shown to colocalize with the topoisomerase I-interacting proteins BTBD1 and BTBD2 in punctate or elongated cytoplasmic bodies in several mouse and human cells where it appears to serve as a scaffold for the assembly of endogenous BTBD proteins. TRIM5δ also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner.4
Background	TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region.¹ TRIM5 has five alternately spliced isoforms, the longest of which is the variant which also contains a carboxy-terminal B30.2 (SPRY) domain.¹ Expression of TRIM5α variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, ^{2, 3} albeit at differing efficiencies. The TRIM5δ isoform has been shown to colocalize with the topoisomerase I-interacting proteins BTBD1 and BTBD2 in punctate or elongated cytoplasmic bodies in several mouse and human cells where it appears to serve as a scaffold for the assembly of endogenous BTBD proteins. TRIM5δ also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner.⁴
PubMed	TRIM5δ
Manufacturer - Specificity	Rabbit Anti-Human TRIM5δ recognizes Human TRIM5δ. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2831904
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

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LEIN-T335-0.5mg-safety-datasheet.pdf