Anti-Human TNF-α [Clone 1825] - 500 µg

N

TNF-α

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TNF-α is a 17.5 kD protein that mediates inflammation and immunity caused by the invasion of viruses, bacteria, and parasites by initiating a cascade of cytokines that increase vascular permeability, thus bringing macrophages and neutrophils to the site of infection. TNF-α secreted by the macrophage causes the blood to clot which provides containment of the infection. TNF-α binding to surface receptors brings about various biologic activities that include cytolysis and cytostasis of many tumor cell lines In vitro, hemorraghic necrosis of tumors In vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.

Neutralization: This antibody is useful for neutralization of Human TNF-α bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human TNF-α (at 0.25 ng/ml) is 0.02 - 0.04 µg/ml.

Clone 1825 recognizes an epitope on human TNF-α.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Purified Recombinant Human TNF-α (Accession # P01375)

Monoclonal Antibody, Tumor Necrosis Factor Alpha, TNFSF1A, TNFSF2, Cachectin, Differentiation-Inducing Factor [DIF], Necrosin, Cytotoxin, 1825, TNF-α, Human, Anti-Human TNF-α, APC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-derived, tnfa, tnf-a, TNFalpha, TNF-alpha, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFSF1A, TNFSF2, TNFSF2TNF superfamily, member 2, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor, tumor necrosis factor-alpha