Anti-Human Tie-1 (Clone 88016) - 500 µg

ICC, IHC FFPE, WB

Tie-1

Next Day Ambient

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (Tie-1) are novel endothelial cell tyrosine kinase receptors that are essential for vascular development and remodeling in the embryo.1 They are expressed almost exclusively in endothelial cells.2Tie-1 also have a role in the regulatory pathways of early hematopoiesis and angiogenesis.3 It is upregulated in diseases such as atherosclerosis and rheumatoid arthritis.4

IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 25 µg/ml. The recommended secondary antibody for IHC is PN:M114. For chromogenic detection with high signal and low background use PN:D100 or PN:K107.
Immunocytochemistry: Suitable for use at concentration of 8-25 µg/mL.

Mouse Anti-Human Tie-1 (Clone 88016) recognizes an epitope on Human Tie-1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

NS0-Derived Recombinant Human Tie-1 Extracellular Domain (Accession # P35590)

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