Anti-Human TACE Ectodomain (Clone 111623) - 500 µg

Primary Monoclonal Antibodies>Growth Factors and Cytokines

USA

The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

TACE (tumor necrosis factor-α-converting enzyme) is a pleiotropic metalloprotease also known as ADAM17 that is found to be constitutively expressed by intestinal epithelial cells.¹ TACE is a major sheddase of TNF-α and its receptors, essential for the generation of soluble, mature molecules.² TACE as a promising target of epidermal growth factor receptor (EGFR) axis inhibition in colorectal cancer (CRC)³ and a principal target for the treatment of TNF-dependent pathologies.⁴

TACE Ectodomain

AB_2831961

T. ni Cell-Derived Recombinant Human TACE (Accession # P78536)

Monoclonal Antibody, Tumor Necrosis Factor-α Converting Enzyme, ADAM17, CD156b, MGC71942, cSVP, 111623, TACE, Human, Anti-Human TACE Ectodomain, ADAM 17, ADAM metallopeptidase domain 17, ADAM metallopeptidase domain 18, ADAM17, ADAM18, CD156b antigen, CD156b, CSVP, disintegrin and metalloproteinase domain-containing protein 17, EC 3.4.24.86, MGC71942, Snake venom-like protease, TACE, TACEcSVP, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha-converting enzyme, tumor necrosis factor, alpha, converting enzyme