ArtNr |
LEIN-T954-25mg |
Hersteller |
Leinco Technologies
|
Menge |
25 mg |
Quantity options |
1 mg
100 mg
25 mg
5 mg
50 mg
|
Kategorie |
|
Typ |
Antibody Monoclonal |
Applikationen |
WB, FC, IP, ELISA, other, IV |
Clon |
TR75-54.7 |
Specific against |
Mouse (Murine, Mus musculus) |
Host |
Hamster - Armenian |
Purity |
> 95% by SDS-PAGE and ≥ 98% monomer by analytical SEC |
Citations |
1. Zuckerman, KS. et al. (1998) Cancer Res. 58:2217. 2. Sheehan, KC. et al. (1995) J. Exp. Med. 181:607. |
NCBI |
21938 |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Versandbedingung |
Gekühlt |
Lieferbar |
|
Manufacturer - Applications |
Quality Tested by Leinco FC The suggested concentration for clone TR75-54.7 antibody for staining cells in flow cytometry is ≤ .25 μg per 106 cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application. |
Manufacturer - Category |
Primary Monoclonal Antibodies>Growth Factors and Cytokines|Purified in vivo Functional Grade>Platinum Purified Bulk Antibodies|Purified in vivo Functional Grade |
Manufacturer - Targets |
TNFR2 |
Country of Origin |
USA |
Shipping Temperature |
Next Day 2-8°C |
Storage Conditions |
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
Product Description |
Tumor necrosis factor receptor II (TNF-RII) is present on most cell types1 and is considered to play a prominent role in stimulation by TNF-alpha. TNFRII proteins are expressed by hematopoietic cells including macrophages, neutrophils, lymphocytes, thymocytes and mast cells. It is expressed by a variety of other cell types including endothelial cells, cardiac myocytes and prostate cells.2 |
Background |
Tumor necrosis factor receptor II (TNF-RII) is present on most cell types1 and is considered to play a prominent role in stimulation by TNF-alpha. TNFRII proteins are expressed by hematopoietic cells including macrophages, neutrophils, lymphocytes, thymocytes and mast cells. It is expressed by a variety of other cell types including endothelial cells, cardiac myocytes and prostate cells.2 |
Pathogen Testing |
To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Leinco’s Purified Functional PLATINUM™ antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile. |
Function |
Apoptosis, NF-κB activation, inflammation, tumor necrosis, cell differentiation |
Other Applications Reported In Literature |
IP B WB ELISA Cap |
PubMed |
TNFR2 |
Ligand/Receptor |
TNF-α, LT-α (TNF-β) |
Manufacturer - Research Area |
Immunology, Innate Immunity |
Manufacturer - Specificity |
Anti-Mouse CD120 recognizes Mouse CD120. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. |
RRID |
AB_2832125 |
Concentration |
≥ 5.0 mg/ml |
Formulation |
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration. |
Product Preparation |
Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
Antigen Distribution |
Variety of cell types at low levels |
Endotoxin Level |
≤ 0.5 EU/mg |
Immunogen |
Purified Recombinant Mouse TNF R2 |
Additional Information |
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.