IRAK Antibody

ArtNr	PRS-1007-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Oncology Neuroscience Neuroinflammation Antibodies By Cell Type Hematology Leukemia Lymphoma Immunoprecipitation Western Blot ELISA Immunofluorescence Immunocytochemistry Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IP, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Schauvliege et al. Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases. FEBS Lett. 2006;580(19):4697-702. PMID: 16884718 Ahmad et al. MyD88, IRAK1 and TRAF6 knockdown in human chondrocytes inhibits interleukin-1-induced matrix metalloproteinase-13 gene expression and promoter activity by impairing MAP kinase activation. Cell Signal. 2007 ;19(12):2549-57. PMID: 17905570 Ahmad et al. Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation. J Inflamm (Lond). 2012;9(1):48. PMID: 23191980 Cao et al. Science 1996;271:1128-31. Trofimova et al. J Bio Chem 1996; 271: 17609-1. Huang et al. Proc Natl Acad Sci USA 1997;94:12829-12832. Robinson et al. Immunity 1997;7:571-581.
NCBI	IRAK1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	IRAK Antibody: IRAK, pelle, IRAK, Interleukin-1 receptor-associated kinase 1, IRAK-1
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Manufacturer - Applications	WB: 1-4 μg/mL; IF: 20 μg/mL; ICC: 10 μg/mL. Antibody validated: Western Blot in human, mouse and rat samples; Immunofluorescence and Immunocytochemistry in human samples. All other applications and species not yet tested.
Shipping Temperature	blue ice or room temperature
Storage Conditions	IRAK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	Predicted: 77kD Observed: 77 kD
Manufacturer - Research Area	Signal Transduction, Innate Immunity
Background	IRAK Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κ B activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
Protein Gi #	8928535
Purification	IRAK Antibody is affinity chromatography purified via peptide column.
Isoforms	Human IRAK has 4 isoforms, including isoform 1 (712aa, 77kD), isoform 2 (682aa, 73kD), isoform 3 (693aa, 75kD), and isoform 4 (633aa, 68kD). Mouse IRAK has 2 isoforms, including isoform 1 (710aa, 77kD) and isoform 2 (712aa, 78kD). Rat IRAK also has one isoform (710aa, 78kD). 1007 can detect all human isoforms, mouse and rat IRAK.
Positive Control 1	PRS-1201-0.1mg
Positive Control 2	PRS-17-001-1pack
Positive Control 3	PRS-1220-0.1mg
Concentration	1 mg/ml
Buffer	IRAK Antibody is supplied in PBS containing 0.02% sodium azide.
Homology	Predicted species reactivity based on immunogen sequence: Bovine: (85%)
Manufacturer - Specificity	At least four isoforms of IRAK are known to exist; this antibody will detect all four isoforms. IRAK antibody is predicted to not cross-react with other members of the IRAK protein family.
Immunogen	Anti-IRAK antibody (1007) was raised against a peptide corresponding to 13 amino acids near the carboxy terminus of human IRAK. The immunogen is located within the last 50 amino acids of IRAK.
Clonality	Polyclonal
NCBI Official Name	interleukin-1 receptor-associated kinase 1
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

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