GFR alpha 2 Antibody

blue ice or room temperature

Predicted: 51 kDa
Observed: 52 kDa

GFR alpha 2 Antibody: Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRalpha, which is a cell surface receptor for NTN. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently. NTNRalpha was also termed GDNFRβ , Ret ligand 2 (RETL2) or TGFbeta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRα -2 recently. GFRα -2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRα -2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.

GFR alpha 2 Antibody is Ion exchange chromatography purified.

PRS-17-001-1pack

GFR alpha 2 Antibody is supplied in PBS containing 0.02% sodium azide.

GFR alpha 2 antibody was raised against a 15 amino acid peptide near the center of human GFR alpha 2.

The immunogen is located within amino acids 360 - 410 of GFR alpha 2.

GDNF family receptor alpha 2

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.