SODD Antibody

Blue Ice

60 kDa

SODD Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

Trial Size

4160013

PRS-1201-0.1mg

PRS-17-001-1pack

SODD Antibody is supplied in PBS containing 0.02% sodium azide.

SODD antibody was raised against a peptide corresponding to amino acids near the amino terminus of human SODD.

The immunogen is located within the first 50 amino acids of SODD.

BCL2-associated athanogene 4

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.