Survivin Antibody

ArtNr	PRS-2235-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Melanoma Cell Biology Cell Status Western Blot ELISA Immunofluorescence Immunocytochemistry Autophagy Primary Antibodies By Organ Breast Cancer Neuronal Cell Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ICC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Ambrosini et al. Nat Med 1997;3:917-21. Li et al. Nature 1998;396:580-4. Kobayashi et al. Proc Natl Acad Sci USA 1999;96:1457-62 (WD0600). Zhang et al. Antibody detectionusing tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma. J Hepatol. 2007;46(1):107-14. PMID: 17067715 Megliorino et al. Autoimmune response to anti-apoptotic protein survivin and its association with antibodies to p53 and c-myc in cancer detection. Cancer Detect Prev. 2005;29(3):241-8. PMID: 15896923 Li et al. Detection of autoantibodies to multiple tumor-associated antigens in the immunodiagnosis of ovarian cancer. Mol Med Rep. 2008;1(4):589-94. PMID: 20523766
NCBI	BIRC5
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Survivin Antibody: API4,EPR-1,API4,IAP4,Baculoviral IAP repeat-containing protein 5,Apoptosis inhibitor 4
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	Survivin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	Predicted: 17kD Observed: 17 kD
Manufacturer - Research Area	Apoptosis, Cancer
Background	Survivin Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.
By Type	Apoptosis, Cancer
Badges	Trial Size, IAV
Modifications	None
Protein Gi #	59859878
Purification	Survivin Antibody is affinity chromatography purified via peptide column.
Isoforms	Human Survivin has 7 isoforms, including isoform 1 (142aa, 16kD), isoform 2 (165aa, 19kD), isoform 3 (137aa, 16kD), isoform 4 (120aa, 14kD), isoform 5 (117aa, 14kD), isoform 6 (78aa, 9kD) and isoform 7 (74aa, 8.5kD). Mouse Survivin has 3 isoforms, including isoform 1 (140aa, 16kD), isoform 2 (121aa, 14kD) and isoform 3 (40aa, 4.7kD). Rat Survivin has one isoform (142aa, 17kD). 2235 can detect human and possibly mouse and rat.
Validation	Independent Antibody Validation in Cell lines (Figure 2) shows similar Survivin expression profile in human cell lines detected by two independent anti-Survivin antibodies that recognize different epitopes, 2233 against N-terminus domain and 2235 against C-terminus domain. Survivin proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Recombinant Protein Test (Figure 6- 8): Anti-Survivin antibodies (2235) detected human Survivin recombinant protein directly or in sera from cancer patients.
Positive Control 1	PRS-1206-0.1mg
Positive Control 2	PRS-17-006-1pack
Positive Control 3	PRS-1201-0.1mg
Positive Control 4	PRS-1204-0.1mg
Positive Control 5	PRS-1224-0.1mg
Concentration	1 mg/ml
Buffer	Survivin Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	WB: 1-5 μ g/mL; ICC: 10 μ g/mL; IF: 10 μ g/mL. Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples; Immunofluorescence in human samples. All other applications and species not yet tested.
Homology	Predicted species reactivity based on immunogen sequence: Pig: (92%), Bovine: (79%), Mouse: (71%), Rat: (71%)
Immunogen	Anti-Survivin antibody (2235) was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human Survivin. The immunogen is located within the last 50 amino acids of Survivin.
Clonality	Polyclonal
NCBI Official Name	baculoviral IAP repeat-containing 5
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

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