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Survivin Antibody

ArtNr PRS-2237-0.1mg
Hersteller ProSci
Menge 0.1 mg
Quantity options 0.02 mg 0.1 mg
Kategorie
Typ Antibody Polyclonal
Format Liquid
Applikationen WB, ELISA, IHC-P
Specific against Mouse (Murine, Mus musculus)
Host Rabbit
Isotype IgG
Konjugat/Tag Unconjugated
Citations Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997;3:917-21
Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC, Altieri DC. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998;396:580-4
Kobayashi K, Hatano M, Otaki M, Ogasawara T, Tokuhisa T. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc Natl Acad Sci USA 1999;96:1457-62 (WD1000)
NCBI BIRC5
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Survivin Antibody: API4,EPR-1,API4,IAP4,Baculoviral IAP repeat-containing protein 5,Apoptosis inhibitor 4
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Type
Primary Antibodies
Shipping Temperature
Blue Ice
Storage Conditions
mSurvivin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight
17 kDa
Manufacturer - Research Area
Apoptosis
Background
Survivin Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.
By Type
Apoptosis
Badges
Trial Size
Modifications
None
Protein Gi #
59859878
Purification
Survivin Antibody is affinity chromatography purified via peptide column.
Positive Control 1
PRS-1406-0.1mg
Concentration
1 mg/ml
Buffer
Survivin Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note
mSurvivin antibody can be used for detection of survivin by Western blot at 1 μ g/mL. An approximate 17 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 10 μ g/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Homology
Predicted species reactivity based on immunogen sequence: Rat: (83%)
Immunogen
Survivin antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of mouse Survivin.

The immunogen is located within the last 50 amino acids of Survivin.
Clonality
Polyclonal
NCBI Official Name
baculoviral IAP repeat-containing 5
NCBI Organism
Homo sapiens
Disclaimer
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note
Optimal dilutions for each application to be determined by the researcher.
Survivin Antibody
Survivin Antibody
Survivin Antibody
Survivin Antibody
Survivin Antibody
Survivin Antibody

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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