ASC Antibody

ArtNr	PRS-2287-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Oncology Antibodies Immunohistochemistry Western Blot ELISA Immunocytochemistry Primary Antibodies By Organ Breast Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ICC, ELISA, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Masumoto et al. J Biol Chem. 1999;274(48):33835-8. Masumoto et al. Exp Cell Res. 2001;262(2):128-133. Conway et al. Cancer Res. 2000;60(22):6236-42 McConnell et al. Cancer Res. 2000;60(22):6243-7. (WD0102) Dowds et al. Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem. 2004;279(21):21924-8. PMID: 15020601
NCBI	PYCARD
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ASC Antibody: ASC,TMS,TMS1,CARD5,TMS-1,ASC,Apoptosis-associated speck-like protein containing a CARD,Caspase recruitment domain-containing protein 5,hASC
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	ASC antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	Predicted: 22kD Observed: 22 kD
Manufacturer - Research Area	Apoptosis
Background	ASC Antibody: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3, 4). Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.
By Type	Apoptosis, Inflammasomes
Badges	Trial Size, IAV, KD, Most Cited
Modifications	None
Protein Gi #	10801602
Purification	ASC Antibody is affinity chromatography purified via peptide column.
Isoforms	Human ASC has 3 isoforms, including isoform 1 (195aa, 22kD), isoform 2 (176aa, 20kD), and isoform 3 (135aa, 15kD). Mouse ASC has one isoform (193aa, 22kD) and rat ASC also has one isoform (193aa, 22kD). 2287 can detect all human isoforms.
Validation	Independent Antibody Validation in Cell lines (Figure 2) shows similar ASC expression profile in human and mouse cell lines detected by two independent anti-ASC antibodies that recognize different epitopes, 2287 against C-terminus domain and 39-001 against full length human recombinant protein. ASC proteins are detected in some of tested cell lines at different expression levels by the two independent antibodies.
Positive Control 1	PRS-1209-0.1mg
Positive Control 2	PRS-17-009-1pack
Positive Control 3	PRS-10-901-4um
Positive Control 4	PRS-1208-0.1mg
Concentration	1 mg/mL
Buffer	ASC Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	WB: 1-2 μ g/mL; ICC: 5 μ g/mL; IHC-P: 2.5 μ g/mL. Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples; Immunofluorescence in human samples. All other applications and species not yet tested.
Homology	Predicted species reactivity based on immunogen sequence: Mouse (57%), Rat (57%)
Immunogen	Anti-ASC antibody (2287) was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human ASC. The immunogen is located within the last 50 amino acids of ASC.
Clonality	Polyclonal
NCBI Official Name	PYD and CARD domain containing
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkt-Datenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 0.02 mg

lieferbar

Lieferung vsl. bis 05.02.2026

Express-Lieferung: 17 Tage sparen

Technische Frage stellen

Bulk-Anfrage stellen

Bestellen Sie passend dazu:

HL60 Lysate erfolgreich zu Ihrem Warenkorb hinzugefügt.

HL60 Lysate

Auf Anfrage

Menge: 0.1 mg

Anmelden
ASC Peptide erfolgreich zu Ihrem Warenkorb hinzugefügt.

ASC Peptide

Auf Anfrage

Menge: 0.05 mg

Anmelden

Fragen zum Produkt?

sales@hoelzel.de

Zuletzt angesehen

Urokinase-type plasminogen activator
SIW-AP88985-100ug

Schließen

« Zurück

ASC Antibody

Kontakt

Über Hölzel

Service

Infothek

ANMELDEN & VORTEILE SICHERN

ASC Antibody

Kontakt

Über Hölzel

Service

Infothek