DcR1 Antibody

Blue Ice

65 kDa

DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

Trial Size

2338421

PRS-1201-0.1mg

PRS-1464-0.1mg

DcR1 Antibody is supplied in PBS containing 0.02% sodium azide.

DcR1 antibody was raised against a peptide corresponding to amino acids in the extracellular domain of human DcR1 precursor.

The immunogen is located within amino acids 90 - 140 of DcR1.

tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.