CIDE-B Antibody

Blue Ice

Predicted: 25 kD

Observed: 26 kD

CIDE-B Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes and bone marrow.

Trial Size

6746626

PRS-1306-0.1mg

PRS-1408-0.1mg

1 mg/ml

WB: 1-2 μ g/mL; IHC-P/IF: 5-20 μ g/mL.

Antibody validated: Western Blot in human, mouse and rat samples; Immunofluorescence in the human, mouse and rat samples. All other applications and species not yet tested.

CIDE-B antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human CIDE-B.

The immunogen is located within the last 50 amino acids of CIDE-B.

cell death-inducing DFFA-like effector b

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.