PID Antibody

Blue Ice

Predicted: 73 kDa
Observed: 75 kDa

PID Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex. PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis. PID/MTA2 is ubiquitously expressed in human tissues.

Trial Size

9931638

PRS-1201-0.1mg

1 mg/mL

PID antibody can be used for detection of PID by Western blot at 1 μ g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL and Immunohistochemistry starting at 2.5 μ g/mL. For immunofluorescence start at 10 μ g/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

PID antibody was raised against a 17 amino acid peptide near the carboxy terminus of human PID.

The immunogen is located within the last 50 amino acids of PID.

metastasis associated 1 family, member 2

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.