CIKS Antibody

blue ice or room temperature

63 kDa

CIKS Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κ B associates with Iκ B proteins in the cell cytoplasm, which inhibit NF-κ B activity. Iκ B is phosphorylated by Iκ B kinase (IKK) complex that contains IKKα , IKKβ , and IKKγ . A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-κ B activator 1). CIKS directly interacts with IKKγ . CIKS/Act1 also activates activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). These results indicate that CIKS/Act1 is involved in the inflammation and stress responses. CIKS/Act1 is ubiquitously expressed in human tissues.

CIKS Antibody is affinity chromatography purified via peptide column.

PRS-1302-0.1mg

1 mg/ml

CIKS antibody was raised against a 14 amino acid peptide near the amino terminus of human CIKS.

The immunogen is located within the first 50 amino acids of CIKS.

TRAF3 interacting protein 2

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.