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AID Antibody

ArtNr PRS-3091-0.1mg
Hersteller ProSci
Menge 0.1 mg
Quantity options 0.02 mg 0.1 mg
Kategorie
Typ Antibody Polyclonal
Format Liquid
Applikationen WB, IF, ICC, ELISA
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host Rabbit
Isotype IgG
Konjugat/Tag Unconjugated
Citations Muramatsu M, Sankaranand VS, Anant S, et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem. 1999; 274:18470-6.
Muramatsu M, Kinoshita K, Fagarasan S, et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.Cell 2000; 102:553-63.
Greeve J, Philipsen A, Krause K, et al. Expression of activation-induced cytidine deaminase in human B-cell Hodgkin lymphomas. Blood 2003; 101:3574-80.
Cascalho M. Advantages and disadvantages of cytidine deamination. J. Immunol. 2004; 172:6513-8.
NCBI AICDA
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias AID Antibody: AID,ARP2,CDA2,HIGM2,HEL-S-284,AID,Single-stranded DNA cytosine deaminase,Activation-induced cytidine deaminase
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Type
Primary Antibodies
Shipping Temperature
Blue Ice
Storage Conditions
AID antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight
Predicted: 22 kDa
Observed: 25 kDa
Manufacturer - Research Area
Immunology
Background
AID Antibody: Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. It is necessary for somatic hypermutation and class switch recombination in B cells, but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms. Although it is structurally and functionally similar to the APOBEC proteins, it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.
By Type
Immunology
Badges
Trial Size
Modifications
None
Protein Gi #
22297218
Purification
AID Antibody is affinity chromatography purified via peptide column.
Positive Control 1
PRS-1225-0.1mg
Concentration
1 mg/mL
Buffer
AID Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note
AID antibody can be used for detection of AID by Western blot at 2 μ g/mL. Anti-AID is human and mouse reactive. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen
AID antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human AID.

The immunogen is located within the last 50 amino acids of AID.
Clonality
Polyclonal
NCBI Official Name
activation-induced cytidine deaminase
NCBI Organism
Homo sapiens
Disclaimer
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note
Optimal dilutions for each application to be determined by the researcher.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.1 mg
Lieferbar: In stock
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