TLR4 Antibody

Primary Antibodies

TLR4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

TLR4 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-κ B. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

Trial Size

19924149

1 mg/mL

TLR4 antibody can be used for detection of TLR4 by immunohistochemistry at 5 μ g/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

TLR4 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TLR4.

The immunogen is located within the last 50 amino acids of TLR4.

toll-like receptor 4

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.