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TLR4 Antibody

ArtNr PRS-3141-0.02mg
Hersteller ProSci
Menge 0.02 mg
Quantity options 0.02 mg 0.1 mg
Kategorie
Typ Antibody Polyclonal
Format Liquid
Applikationen WB, IF, ICC, ELISA, IHC-P
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Konjugat/Tag Unconjugated
Citations Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
NCBI TLR4
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias TLR4 Antibody: TOLL,CD284,TLR-4,ARMD10,Toll-like receptor 4,hToll
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Type
Primary Antibodies
Shipping Temperature
Blue Ice
Storage Conditions
TLR4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight
Predicted: 92 kDa
Observed: 94 kDa
Manufacturer - Research Area
Innate Immunity
Background
TLR4 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-κ B. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
By Type
Innate Immunity, Inflammasomes
Badges
Trial Size
Modifications
None
Protein Gi #
19924149
Purification
TLR4 Antibody is affinity chromatography purified via peptide column.
Positive Control 1
PRS-1308-0.1mg
Positive Control 2
PRS-1204-0.1mg
Positive Control 3
PRS-17-004-1pack
Concentration
1 mg/mL
Buffer
TLR4 Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note
TLR4 antibody can be used for detection of TLR4 by Western blot at 2 to 4 μ g/mL. Antibody can also be used for immunocytochemistry starting at 2 μ g/mL and Immunohistochemistry starting at 2.5 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (80%), Horse: (73%), Rat: (71%), Pig: (73%)
Immunogen
TLR4 antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of human TLR4.

The immunogen is located within amino acids 30 - 80 of TLR4.
Clonality
Polyclonal
NCBI Official Name
toll-like receptor 4
NCBI Organism
Homo sapiens
Disclaimer
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note
Optimal dilutions for each application to be determined by the researcher.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.02 mg
Lieferbar: In stock
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