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PHAP Antibody

ArtNr PRS-3152-0.02mg
Hersteller ProSci
Menge 0.02 mg
Quantity options 0.02 mg 0.1 mg
Kategorie
Typ Antibody Polyclonal
Format Liquid
Applikationen WB, IF, ELISA, IHC-P
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Konjugat/Tag Unconjugated
Citations Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC , Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science. 2003;299(5604):223-6.
Nicholson DW, Thornberry NA. Apoptosis. Life and death decisions. Science. 2003 10;299(5604):214-5.
NCBI ANP32A
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias PHAP Antibody: LANP,MAPM,PP32,HPPCn,PHAP1,PHAPI,I1PP2A,C15orf1,LANP,Acidic leucine-rich nuclear phosphoprotein 32 family member A,Acidic nuclear phosphoprotein pp32
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Type
Primary Antibodies
Shipping Temperature
Blue Ice
Storage Conditions
PHAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight
35 kDa
Manufacturer - Research Area
Apoptosis
Background
PHAP Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
By Type
Apoptosis
Badges
Trial Size
Modifications
None
Protein Gi #
730318
Purification
PHAP Antibody is DEAE purified.
Positive Control 1
PRS-1207-0.1mg
Positive Control 2
PRS-1308-0.1mg
Positive Control 3
PRS-11-801-4um
Concentration
1 mg/mL
Buffer
PHAP Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note
PHAP antibody can be used for detection of PHAP I and PHAP III by Western blot at 1 μ g/mL. At approximately 35 kDa and 32 kDa a band can be detected. Antibody can also be used for immunohistochemistry starting at 10 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (85%)
Immunogen
PHAP antibody was raised with a synthetic peptide corresponding to amino acids at carboxy terminus of human PHAP I.

The immunogen is located within the last 50 amino acids of PHAP.
Clonality
Polyclonal
NCBI Official Name
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
NCBI Organism
Homo sapiens
Disclaimer
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note
Optimal dilutions for each application to be determined by the researcher.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.02 mg
Lieferbar: In stock
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