CARMA1 Antibody

Primary Antibodies

CARMA1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

CARMA1 Antibody: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the Iκ K complex, thereby regulating activation of the NF-κ B transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.

Trial Size

172046231

PRS-1409-0.1mg

CARMA1 Antibody is supplied in PBS containing 0.02% sodium azide.

CARMA1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1.

The immunogen is located within the last 50 amino acids of CARMA1.

caspase recruitment domain family, member 11

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.