Bid Antibody

Primary Antibodies

Bid antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Bid Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bid, a pro-apoptotic Bcl-2 family member, is cleaved by caspase-8 in response to apoptotic signals, exposing the Bcl-2 homology 3 (BH3) domain which is normally buried in the full-length protein. The cleaved complex is myris-toylated and translocated to the mitochondrial membrane where it may induce mitochondrial Bax and Bak to oligomerize.

Trial Size

54673639

PRS-1203-0.1mg

Bid Antibody is supplied in PBS containing 0.02% sodium azide.

Bid antibody was raised against a peptide corresponding to 14 amino acids near the middle of human Bid.

The immunogen is located within amino acids 100 - 150 of Bid.

BH3 interacting domain death agonist

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.