TRIAD3A Antibody

Blue Ice

Predicted: 95 kDa
Observed: 95 kDa

TRIAD3A Antibody: Activation of NF-κ B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88. Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR. Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9; this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation.

Trial Size

31324099

PRS-1401-0.1mg

TRIAD3A Antibody is supplied in PBS containing 0.02% sodium azide.

TRIAD3A antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of mouse TRIAD3A.

The immunogen is located within amino acids 120 - 170 of TRIAD3A.

ring finger protein 216

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.