IRF8 Antibody

Primary Antibodies

IRF8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IRF8 Antibody: Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases, but IRF8 mediates activation of NF-κ B by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells. Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia.

Trial Size

IRF8 Antibody is affinity chromatography purified via peptide column.

PRS-17-004-1pack

IRF8 Antibody is supplied in PBS containing 0.02% sodium azide.

IRF8 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human IRF8.

The immunogen is located within the last 50 amino acids of IRF8.

interferon regulatory factor 8

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.