Beclin-1 Antibody

Primary Antibodies

Beclin-1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Beclin-1 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death.

Trial Size

16307457

PRS-1202-0.1mg

1 mg/mL

Beclin-1 antibody can be used for the detection of Beclin-1 by Western blot at 0.5 - 2 μ g/mL. Antibody can also be used for immunocytochemistry starting at 1 μ g/mL. For immunofluorescence start at 2 μ g/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beclin-1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Beclin-1.

The immunogen is located within the last 50 amino acids of Beclin-1.

beclin 1, autophagy related

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.