Beclin-1 Antibody

Blue Ice

Predicted: 52 kD
Observed: 60 kD

Beclin-1 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death.

Trial Size, KD, Cell Treatment

16307457

Human Beclin-1 has one isoform (450aa, 52kD). Mouse Beclin-1 has one isoform (448aa, 52kD) and Rat Beclin-1 also has one isoform (448aa, 52kD). 3613 can detect human, mouse and rat.

PRS-1401-0.1mg

PRS-1461-0.1mg

Beclin-1 Antibody is supplied in PBS containing 0.02% sodium azide.

Predicted species reactivity based on immunogen sequence: Bovine: (94%), Pig: (88%)

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.