TLR3 Antibody

Blue Ice

Predicted: 88 kDa
Observed: 91 kDa

TLR3 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.

Trial Size

20140422

PRS-1287-0.1mg

1 mg/mL

TLR3 antibody can be used for detection of TLR3 by Western blot at 0.5 μ g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL. For immunofluorescence start at 2 μ g/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

TLR3 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR3.

The immunogen is located within amino acids 40 - 90 of TLR3.

toll-like receptor 3

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.