TLR6 Antibody

Blue Ice

Observed: 91 kDa

TLR6 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses.

Trial Size

20143971

PRS-1224-0.1mg

1 mg/mL

TLR6 antibody can be used for detection of TLR6 by Western blot at 1 μ g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR6.

The immunogen is located within amino acids 160 - 210 of TLR6.

toll-like receptor 6

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.