IL-31 Antibody

Primary Antibodies

IL-31 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IL-31 Antibody: Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

Trial Size

46276465

PRS-1375-0.1mg

IL-31 Antibody is supplied in PBS containing 0.02% sodium azide.

IL-31 antibody was raised against a 18 amino acid synthetic peptide from near the center of human IL-31.

The immunogen is located within amino acids 60 - 110 of IL-31.

interleukin 31

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.