Hrk Antibody

Blue Ice

Predicted: 10 kDa
Observed: 12 kDa

Hrk Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.

Trial Size

4504493

PRS-1414-0.1mg

Hrk Antibody is supplied in PBS containing 0.02% sodium azide.

HRK antibody was raised against a 15 amino acid synthetic peptide from near the center of human Hrk.

The immunogen is located within the last 50 amino acids of Hrk.

harakiri, BCL2 interacting protein (contains only BH3 domain)

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.