PRTFDC1 Antibody

PRTFDC1 antibody can be used for detection of PRTFDC1 by Western blot at 1 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

PRTFDC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

PRTFDC1 Antibody: Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.

PRTFDC1 Antibody is affinity chromatography purified via peptide column.

1 mg/ml

Predicted species reactivity based on immunogen sequence: Chicken: (86%), Pig: (86%), Bovine: (86%), Mouse: (86%)

Polyclonal

Homo sapiens