ABIN3 Antibody

blue ice or RT

ABIN3 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ABIN3.

The immunogen is located within the last 50 amino acids of ABIN3.

Cat. No. 1306 - Human Spleen Tissue Lysate

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 5303P – ABIN3 Peptide

None

NP_079149

79931

TNIP3

Homo sapiens

ABIN3 Antibody: The nuclear factor NF-κ B plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-κ B activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-κ B activation. ABIN3 is a 39 kDa protein that negatively regulates NF-κ B activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-κ B inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-κ B in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.

Bouwmeester T, Bauch A, Ruffner H, et al. A physical and functional map of the human TNFα /NFkappaB signal transduction pathway. Nat. Cell Biol.2004; 6:97-105.

Weaver BK, Bohn E, Judd BA, et al. Abin-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions. Mol. Cell. Biol.2007; 27:4603-16.

Immunohistochemistry of ABIN3 in mouse spleen tissue with ABIN3 antibody at 5 μ g/mL.